Downregulated Dicer expression predicts poor prognosis in chronic lymphocytic leukemia
نویسندگان
چکیده
منابع مشابه
Dicer Gene Expression as a Prognostic Factor in Acute Lymphoblastic Leukemia and Chronic Lymphocytic Leukemia in Fars Province
Alterations in the expression of microRNAs (miRNAs) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL). Dicer is one of the main regulators of miRNA biogenesis, and deregulation of its expression has been indicated as a possible cause of miRNA alterations observed in various cancers. Our aim was to analyze the expre...
متن کاملdicer gene expression as a prognostic factor in acute lymphoblastic leukemia and chronic lymphocytic leukemia in fars province
alterations in the expression of micrornas (mirnas) have been proposed to play a role in the pathogenesis of acute lymphoblastic leukemia (all) and chronic lymphocytic leukemia (cll). dicer is one of the main regulators of mirna biogenesis, and deregulation of its expression has been indicated as a possible cause of mirna alterations observed in various cancers. our aim was to analyze the expre...
متن کاملp53 expression in B-cell chronic lymphocytic leukemia: a marker of disease progression and poor prognosis.
We have analyzed by immunocytochemistry (ICC) the frequency of p53 protein expression in 181 cases of B-cell chronic lymphocytic leukemia (CLL) followed at a single institution to assess the relationship between p53 and the clinical and morphological features of the disease, as well as the possible involvement of this protein in the pathogenesis of the more aggressive forms of CLL. The overall ...
متن کاملReappraising prognosis in chronic lymphocytic leukemia
Baliakas, P. 2016. Reappraising prognosis in chronic lymphocytic leukemia. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1199. 59 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9519-0. Chronic lymphocytic leukemia (CLL) exhibits remarkable clinical heterogeneity likely reflecting the underlying biological heterogeneity. The genetic landscape...
متن کاملChronic Lymphocytic Leukemia (CLL) — Staging and Prognosis
Chronic lymphocytic leukemia (CLL) affects the B-cells of the immune system and is, as the most common leukemia in adults, an important hematological differential diagnosis. It often hardly progresses for years and therefore a CLL does not always need immediate therapy. In the past years especially, a lot has happened with regard to diagnostic options and treatment, so that being informed about...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Science
سال: 2012
ISSN: 1347-9032
DOI: 10.1111/j.1349-7006.2012.02234.x